O2 showed increased VEGF release price. The raise in VEGF secretion rate was transcriptionally driven, as it may be expected (30, 41, 42). The hypoxia-inducible enzyme CA9, overexpressed in cancer cells (26), has been proposed as a marker for hypoxic exposure and tumor aggressiveness (27). Accordingly, we demonstrated that below hypoxic culture CA9 transcripts had been elevated almost by 200-fold
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